4 Major Causes of an Unsuccessful IVF

majour causes of unsuccessfull ivf

IVF (in vitro fertilization) is a kind of infertility treatment. IVF involves many complicated procedures, which finally lead to one’s pregnancy. It is not always certain that a couple going through IVF will get pregnant. Even though IVF treatment is a highly advanced procedure, there have been studies that show that fifty percent of the couples undergoing the procedure don’t end up living their dream of being parents. 

There could be many different reasons for an unsuccessful IVF. If you are undergoing these procedures or planning on doing so, this blog is for you. You can learn about everything that you could be doing to avoid being in a situation where you could face an unsuccessful IVF procedure. 

Keep reading to learn more about all the reasons that could cause IVF failure.

1. Implantation failure of the embryo

This is when the embryo can’t implant itself in the uterus. No particular reason for this has been found as of now. It can be due to issues with the embryo or the uterus. In general, if the embryo is unhealthy, it does not last for more than 4 days. Sometimes, mothers undergo PGS testing before implantation to ensure the embryo is healthy. 

2. Age of the woman

Any woman of fertile age releases an egg from the ovary every month. This egg fuses with the male sperm and forms a zygote. The release of eggs starts decreasing after women reach their 30s. This decrease comes with a decrease in the release of the FSH hormone, which is responsible for reproduction in both males and females. When the process of IVF starts, the female is given medication to increase egg production. When the woman is already in the egg decline phase, these medications don’t turn out to be effective. Thus, fewer fusions happen. If more embryos can be implanted, the chances of a successful IVF treatment increase. 

3. Genetic Causes

Chromosomal, or genetic, abnormalities are the most prominent cause of IVF failure. When a woman has crossed her mid-30s, or is going for the IVF procedure in her 40s, the chances of the embryo having chromosomal abnormalities increase. However, according to some research, it is the sperm that carries most of the chromosomal abnormalities. The abnormalities greatly reduce the rate of success of the IVF procedure. 

4. Embryo Selection:

Embryo selection is the process in IVF where the best embryos are chosen for implantation. Sometimes, it happens that the wrong embryo gets chosen for the implantation process, thus leading to a failure in the IVF process. The defective embryo can survive for a maximum of 7 days, leading to a miscarriage. 


To sum it all up, several reasons might cause an unsuccessful IVF. As we read, there are chances for women in their mid-thirties to face issues. They must be extra cautious and take everything the doctor suggests seriously.

If you’re looking for a place to start your IVF journey or are restarting it, you can contact us at Crysta IVF. Our team of IVF and fertility specialists is available to guide you throughout the process and tell you everything you need to know.

  Verified by Crysta IVF Fertility Experts

Meenakshi Gakhar

Meenakshi Gakhar, with her extensive 8-year background in content creation, specializes in IVF, fertility, and broader healthcare topics. She is dedicated to supporting individuals and couples on their path to parenthood, producing engaging and informative content that demystifies the intricacies of IVF treatments and reproductive health. Her work stands out for its commitment to accuracy, relevance, and compassion, always grounded in the latest healthcare research and advancements. Meenakshi's clear, accessible writing helps readers navigate the complex world of fertility and healthcare with confidence.

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