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What is ICSI (Intra-Cytoplasmic Sperm Injection)?
ICSI, short for Intra-Cytoplasmic Sperm Injection, is an advanced fertility treatment that is often used as part of IVF. In this process, a single healthy sperm is carefully selected and directly injected into an egg to help with fertilisation.
Unlike natural conception, where thousands of sperm compete to reach the egg, ICSI gives one chosen and healthy sperm a direct chance. This method is especially helpful when the male partner has issues like low sperm count, poor sperm movement, or abnormal shape.
In simple words, ICSI increases the chances of fertilisation even when the sperm quality or quantity is very low. It gives many couples struggling with male infertility a real hope of having a biological child.
Why is ICSI Treatment Important for Couples?
ICSI has become one of the most important fertility treatments today because it helps couples overcome problems that once made pregnancy almost impossible. Research shows that ICSI is now used in over 70% of IVF cycles worldwide, especially when male infertility is the main issue.
ICSI is an important treatment because it gives hope to couples who face challenges in conceiving naturally. For many couples, the main hurdle is male infertility issues like low sperm count, poor sperm movement, or sperm not forming properly. In such cases, fertilisation often doesn’t happen even with IVF. ICSI helps overcome this problem by directly injecting a single healthy sperm into the egg, increasing the chances of success.
Who Should Consider ICSI Treatment?
ICSI is a suitable option for couples who are facing severe infertility challenges, especially those linked to sperm problems or repeated IVF failures.
Doctors usually recommend ICSI in the following situations:
- Low Sperm Count : When the male partner does not produce enough sperm for natural fertilisation.
- Poor Sperm Movement or Shape : If sperm cannot move well or have abnormal shapes, they may not be able to reach or penetrate the egg naturally.
- Failed IVF Cycles : When couples have attempted IVF previously, but the eggs did not fertilise properly.
- Surgical Sperm Retrieval : In cases where sperm must be collected directly from the testicles or epididymis due to blockages or absence of sperm in semen.
- Unexplained Infertility : When all reports look normal but fertilisation still does not happen, ICSI can improve the chances.
- Use of Frozen Eggs or Sperm : Sometimes, frozen reproductive cells are less active, and ICSI ensures fertilisation.
Crysta IVF Fertility Expert Advice
“ICSI is not just about solving a medical condition but about giving them the best possible chance at parenthood. If you or your partner are struggling with sperm-related issues or if you’ve faced failed IVF attempts, ICSI can significantly improve the chances of fertilisation.”
Step-by-Step ICSI Procedure
ICSI is an advanced form of IVF, but the main difference is that in ICSI, doctors directly inject one sperm into the egg to improve fertilisation chances. The process is done with care in a fertility lab, step by step:
Step 1 :
Ovarian Stimulation
The female partner is given medication to stimulate the development of follicles in the ovary on Day 2 of her menstruation. The stimulation is done till day 6 or as suggested by the specialist.
Step 2 :
Egg Retrieval
Medication and final stimulation lead to the release of the mature egg. The egg is collected in the clinic and is done by ultrasound guidance under sedation. The retrieved egg is then sent for processing in the ART laboratory.
Step 3 :
Sperm Preparation
Sperm are extracted from the male partner and are then washed and concentrated. Healthy sperm are then collected for further examination.
Step 4 :
Fertilisation in the Lab
The retrieved egg and sperm are sent to the specialised labs for examination by fertility experts. Prior examination of the health of the egg and sperm helps in a smooth and successful ICSI treatment. The healthy sperm is then directly transferred into the cytoplasm of the egg to enhance the chances of fertilisation.
Step 5 :
Embryo Development
After fertilisation, the eggs begin to divide and grow into embryos. These embryos are kept in a special incubator that mimics the conditions of a woman’s womb. Over the next 3–5 days, doctors closely monitor them to assess their growth and quality.
Step 6 :
Pregnancy Test
The best-quality embryo is selected and gently placed into the woman’s uterus. If it implants successfully, pregnancy begins.
ICSI vs IVF: Which One Should You Choose?
ICSI and IVF are both advanced fertility treatments, but they work slightly differently. Understanding these differences can help couples make the right choice.
| Feature | IVF | ICSI |
|---|---|---|
| Fertilization Method | Multiple sperm are placed near the egg in a lab dish and fertilisation happens naturally. | A single healthy sperm is directly injected into the egg to help fertilisation. |
| Best For | Couples with normal sperm count and mild fertility issues. | Couples with severe male infertility, poor sperm quality, or previous IVF failures. |
| Complexity | Less invasive in the lab, standard IVF procedure. | The advanced technique requires a skilled embryologist and special equipment. |
| Cost | Usually slightly lower than ICSI. | Slightly higher due to advanced lab procedures. |
| When Recommended | First choice for most couples unless male infertility is a major factor. | Recommended when sperm cannot fertilise the egg naturally or IVF has failed before. |
Which One to Choose Between ICSI vs IVF?
- Couples with normal sperm and minor fertility issues may start with IVF.
- Couples with low sperm count, poor sperm movement, abnormal sperm shape, or previous IVF failures are often advised to go for ICSI.
- Your fertility specialist will recommend the best option based on tests, medical history, and overall health.
In simple words, IVF is often the starting point, while ICSI is a more advanced solution for specific male infertility challenges. Choosing the right treatment with expert guidance improves your chances of pregnancy.
What is the ICSI Success Rate in India and What Factors Affect It?
The success rate of ICSI in India is quite encouraging and gives hope to many couples. According to research done by Magna Scientia, on average, the ICSI success rate in India ranges between 50% to 80% per cycle, depending on various factors.
This means that almost half or more couples achieve pregnancy with this treatment, making it one of the most reliable fertility options for severe infertility cases.
Factors That Affect ICSI Success Rate in India:
- Age of the Female Partner : Younger women generally have healthier eggs, which improves the chances of fertilisation and pregnancy. Success rates usually decline after the age of 35.
- Quality of Eggs and Sperm : Healthy eggs and good-quality sperm increase the possibility of forming strong embryos.
- Cause of Infertility : If infertility is due to severe male factors, ICSI can bypass many challenges, but overall health conditions also matter.
- Embryo Quality : Embryos that reach the blastocyst stage (Day 5) are more likely to implant successfully.
- Lifestyle and Health : Smoking, alcohol, obesity, stress, and poor diet can reduce success rates, while healthy habits can improve them.
In simple words, ICSI offers high success rates in India, but results depend on age, overall health, and the quality of care at the fertility centre. With the right treatment plan and guidance, many couples can achieve their dream of parenthood through ICSI.
What is the ICSI Treatment Cost in India?
The cost of ICSI treatment in India is usually higher than standard IVF because of the advanced techniques and equipment used. This may change depending on many factors.
Average Cost: On average, the ICSI treatment cost in India ranges between ₹1,50,000 to ₹2,50,000 per cycle.
This may change depending on many factors.
The cost of ICSI treatment in India may vary based on:
- City and Location of the Clinic : Metro cities usually have higher costs than smaller towns.
- Number of Treatment Cycles Needed : Some couples may need more than one cycle for success.
- Additional Procedures : Embryo freezing, laser hatching, or genetic testing (PGT) can result in higher treatment costs.
- Sperm Retrieval Method : If surgical extraction is required, it can increase the cost.
- Hospital Facilities and Technology : Modern labs and equipment may add to the overall charges.
At Crysta IVF, we don’t want cost to stop your dream of becoming parents. That’s why we offer:
- 0% EMI plans (pay in small monthly instalments)
- Flexible financing for treatments and medicines
- Guidance on insurance coverage
Why Choose Crysta IVF for Your Fertility Journey?
20+ Years Experienced Doctors
Crysta IVF has highly experienced doctors who provide accurate treatment according to your problem.
High Success Rate
Crysta IVF brought smiles to 20,000+ of couples’ faces creating a high success rate for conceiving a child.
Personalised Care
Every patient's journey at Crysta IVF is customised to meet their specific needs and circumstances with compassion and care.
Advanced ART Labs
With the use of modern labs and cutting-edge technology, Crysta IVF provides the highest quality of reproductive care.
Transparent Treatment Pricing
Crysta IVF uses a transparent pricing system to improve patient experience and keep patients financially secure.
Trustworthy and Safe
There are no long-term risks or complications associated with the IVF process. Along with its efficacy, Crysta IVF keeps your identity secure.
What are the Benefits vs Risks of ICSI Treatment for Infertility?
ICSI has helped thousands of couples across India achieve pregnancy, especially when male infertility is the main challenge. Like any medical treatment, it has both advantages and limitations. Understanding both can help couples make informed decisions.
Benefits of ICSI
- ICSI can achieve fertilisation even with very low sperm count or poor sperm movement.
- It helps couples with severe male infertility, even if only a few healthy sperm are available.
- It can work for couples who have had failed IVF attempts in the past.
- Couples often get a chance to have their own biological child without using donor sperm.
- ICSI also works well with frozen eggs or sperm in special cases like fertility preservation.
Risks of ICSI
- Fertilisation and pregnancy are not guaranteed in every ICSI cycle.
- There is a chance of multiple pregnancies (twins or triplets) if more than one embryo is transferred.
- The treatment is costlier compared to standard IVF.
- Fertility medicines and procedures may sometimes cause side effects for the mother.
- Some studies suggest a small increase in genetic or birth-related risks, though most ICSI babies are healthy.
What Precautions Should You Take Before and After ICSI Treatment for Better Results?
ICSI is an advanced fertility treatment, and taking the right precautions before and after the procedure can improve your chances of success.
Precautions to Take Before ICSI Treatment
- Maintain a Healthy Lifestyle: Eat balanced meals, stay hydrated, and include fruits, vegetables, and proteins in your diet.
- Avoid Smoking & Alcohol: Excessive smoking and drinking can affect sperm and egg quality.
- Take Prescribed Fertility Medicines Correctly: Follow your doctor’s instructions for hormonal injections and medications.
- Manage Stress: Meditation, yoga, or relaxation exercises can help maintain hormonal balance.
- Undergo all Recommended Tests: Blood tests, scans, and sperm analysis help your doctor plan the treatment effectively.
Precautions to Take After ICSI Treatment
- Rest for a Short Period: Light rest after embryo transfer is recommended, but full bed rest is usually not needed.
- Avoid Strenuous Activity: No heavy lifting, intense workouts, or long travel in the first few days.
- Follow Medication Schedule: Hormonal support medicines should be taken exactly as prescribed.
- Maintain a Healthy Lifestyle: Continue eating nutritious meals and stay hydrated.
- Stay Positive and Relaxed: Emotional health is important during the two-week wait for implantation.
Different Services Offered at Crysta IVF
Different Services Offered at Crysta IVF
Myths around ICSI
A. What is the success rate of ICSI treatment?
Fact: The success rate of ICSI in India generally ranges between 50% to 80% per cycle, depending on factors like the woman’s age, egg and sperm quality, and overall health.
B. Who is ICSI best for?
Fact: ICSI is best for couples facing male infertility issues, such as very low sperm count, poor sperm movement, or abnormal sperm shape. It’s also helpful for couples who have had failed IVF attempts or need surgically retrieved sperm.
C. Is ICSI safe for the baby?
Fact: Yes, ICSI is generally safe. Most babies born through ICSI are healthy.
D. How is ICSI different from IVF?
Fact: In IVF, sperm fertilise the egg naturally in a lab dish. In ICSI, a single healthy sperm is directly injected into the egg to help fertilisation. ICSI is often used when sperm quality or quantity is low, or if IVF has failed before.
E. How much does ICSI cost in India?
Fact: The average cost of ICSI in India ranges from ₹1,50,000 to ₹2,50,000 per cycle. The final cost depends on the clinic, city, fertility medicines, and any additional procedures like embryo freezing or genetic testing.
F. Is ICSI painful for females?
Fact: The procedure itself is mostly painless. Egg retrieval is done under mild anaesthesia, so the woman does not feel pain during the procedure.
G. How long is the treatment for ICSI?
Fact: A single ICSI cycle usually takes around 4 to 6 weeks, including ovarian stimulation, egg retrieval, fertilisation, embryo culture, and embryo transfer.
H. How many rounds of ICSI are needed for a successful pregnancy?
Fact: The number of ICSI cycles needed depends on the couple’s fertility situation. Some couples succeed in the first cycle, while others may require 2–3 cycles to achieve pregnancy.