Sperm DNA Fragmentation and its Implications for Male Fertility

Sperm DNA Fragmentation

Contrary to the popular belief that infertility is the result of reproductive complications in females, sperm DNA fragmentation determines that 50% of most infertility conditions are connected to males only.

You would be surprised to know that all men have some degree of damage to their sperm DNA. This health issue also has a solution, thanks to cutting-edge technology. DFI testing is a type of male fertility test that measures and looks out for the amount of damaged DNA in a sperm sample.

However, due to a lack of awareness and knowledge, many people still do not know how to overcome this health problem that is generating fertility issues in men and making them infertile for the rest of their lives.

To know the solution to sperm DNA fragmentation, its causes, and treatment, let’s get along to comprehend the details carefully, but first, let’s know what exactly is DNA test.

Sperm DNA Fragmentation 

Ideally, sperm fertility detection starts by calculating sperm concentration, motility, and morphology. This evaluation has long been used as the gold standard for determining men’s fertility. Despite this, the examination fails to give a detailed analysis of the genetic structure of the sperm, which is necessary for general embryonic growth.

For accurate analysis and to determine a high degree of DNA injury in cellular sperm material, it is necessary to identify a reason for men’s infertility that traditional assessments fail to identify.

Long story short, sperm DNA fragmentation came with the hope of finding out the trouble of male fertility, taking action towards it, and planning treatment. To plan a proper treatment, you need to know what can be the causes of Sperm Fragmentation. So read on.

What causes Sperm DNA Fragmentation?

The common causes of sperm DNA fragmentation are:

  • Infection 
  • High-fever 
  • Leucocytospermia 
  • High fever 
  • Obesity 
  • Poor eating habits
  • Drug and tobacco usage
  • Advanced-age group 
  • Elevated testicular temperatures
  • Exposure to climatic as well as industrial contaminants

The above-listed causes are the common reasons that lead to sperm DNA fragmentation and trouble with embryo growth. To know more, let’s comprehend the after-effect of Sperm Fragmentation on embryo growth.

Impact of Sperm DNA Fragmentation on embryo growth

The developed embryos from sperm whose DNA is severely fragmented fail to provide an accurate analysis and generate the necessity to undergo a diagnostic test. The higher sperm DNA fragmentation is known to impact embryos from day 2 of growth when the paternal genome starts working.

From there, it starts impairing subsequent blastocyst growth. Moreover, DNA problems in an embryo usually end in cellular degeneration, gene mutations, complications in embryo development, miscarriage, irregularities in the children, and a higher susceptibility to childhood cancer problems.

From maternity to miscarriage 

In couples where the male partner has a high proportion of sperm with fragmented DNA, the likelihood of successful maternity decreases naturally. Research says that present sperm DNA fragmentation assessments have limited capacity to determine a healthy pregnancy. Even research confirms that higher sperm fragmentation is associated with lowered natural maternity, assisted conception maternity, and live birth rates. Not only that, sperm with higher DNA Fragmentation increases the miscarriage percentage from both natural pregnancy and fertility treatment methods.

In an insightful study, we have determined the impact of sperm fragmentation on embryo growth. Now, let’s look at what steps you can take to improve DNA fragmentation in sperm.

How to improve DNA fragmented sperm?

To deal with DNA fragmented sperm, you can follow various strategies to improve the DNA quality, and they are: 

  • Maintain a healthy lifestyle 
  • Avoid harmful substances 
  • Manage stress 
  • Optimize nutrition 
  • Avoid excessive heat exposure 
  • Seek medical advice 

Follow these tips, and you will improve your DNA-fragmented sperm. Also,  if you are considering IVF treatment, let’s check the success of sperm DNA fragmentation in IVF.

How successful is sperm DNA fragmentation in IVF?

The impact of sperm DNA fragmentation on In vitro fertilization (IVF) can vary depending on the severity of fragmentation and other specific individual factors. For your better understanding, we have curated the points to consider.

Lowers fertilization rates 

Studies have shown that elevated levels of sperm DNA fragmentation result in lower fertilization rates during the IVF process. The damaged DNA within the sperm can impair the ability to fertilize an egg successfully. In the end, Sperm Fragmentation drastically affects your pregnancy, even when you opt for IVF treatment.

Reduces fertility potential 

The increased Sperm Fragmentation levels are connected with reduced fertility potential. This higher Sperm fragmentation affects numerous aspects of sperm function, such as embryo development, fertilization development, implantation, and pregnancy rates.

Decreases embryo quality 

It also affects the quality of the embryos developed during the IVF treatment. Generally, it leads to abnormalities in embryonic development, lowers embryo implantation rates, and increases the risk of miscarriage.

Potential impact on pregnancy outcomes 

Several studies say increased sperm DNA fragmentation is linked with a higher risk of miscarriage or pregnancy loss. Sperm with damaged DNA may contribute to genetic abnormalities in embryos, increasing the chances of pregnancy loss. 

These factors vary from individual to individual. For a better outcome and to boost your likelihood of getting pregnant successfully with IVF, it is suggested that you consult a fertility expert. Read on to learn more about how Crysta IVF, the best fertility centre in India, can help you fulfill your dreams and build the family you desire.

Connect with Crysta IVF to start your parenthood journey!

Sperm DNA fragmentation is a complicated condition that makes men unable to conceive with their female partners. Even in IVF treatment, it can turn out to be one of the negative outcomes. Only connecting with an experienced fertility specialist and reaching out to the best IVF centre in Noida or your nearest location can assist you to start a family. 

As India’s most trusted fertility chain, Crysta IVF provides you with well-being along with exceptional care in every step you take to start your family.


From the moment you take your first step to the time your treatment gets completed, the fertility staff along with an IVF specialist makes sure your mental health never gets affected.

Also, the DFI test cost with us isn’t going to put a strain on your pockets. So take your first step to start your family with us, and book your appointment now.

Shivangi Prajapati

Shivangi Prajapati, a writer by profession and passion, has expertise in the healthcare industry. With her extensive research into medical advances, she loves breaking down complex health information, making it easier for people to understand the recent trends in clinical and medical realities. Her dedication to providing trustworthy, relevant, and usable information helps people take good care of their health.

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